کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5558445 | 1561142 | 2017 | 9 صفحه PDF | دانلود رایگان |
- The first study of the relation between Hg in kidney, blood and urine at low U-Hg
- Simultaneous samples were collected from healthy kidney donors.
- There was a linear relationship between mercury in kidney and urine.
- Kidney Hg can be estimated using U-Hg and gender.
- Women have longer half-time of Hg in kidney compared to men.
BackgroundIndividuals without occupational exposure are exposed to mercury (Hg) from diet and dental amalgam. The kidney is a critical organ, but there is limited information regarding the relationship between Hg in kidney (K-Hg), urine (U-Hg), blood (B-Hg), and plasma (P-Hg).ObjectivesThe aim was to determine the relationship between K-Hg, U-Hg, B-Hg, and P-Hg among environmentally exposed individuals, estimate the biological half-time of K-Hg, and provide information useful for biomonitoring of Hg.MethodsKidney cortex biopsies and urine and blood samples were collected from 109 living kidney donors. Total Hg concentrations were determined and the relationships between K-Hg, U-Hg, P-Hg, and B-Hg were investigated in regression models. The half-time of K-Hg was estimated from the elimination constant.ResultsThere were strong associations between K-Hg and all measures of U-Hg and P-Hg (rp = 0.65-0.84, p < 0.001), while the association with B-Hg was weaker (rp = 0.29, p = 0.002). Mean ratios between K-Hg (in μg/g) and U-Hg/24h (in μg) and B-Hg (in μg/L) were 0.22 and 0.19 respectively. Estimates of the biological half-time varied between 30 and 92 days, with significantly slower elimination in women. Adjusting overnight urine samples for dilution using urinary creatinine resulted in less bias in relation to K-Hg or U-Hg/24h, compared with other adjustment techniques.ConclusionsThe relationship between K-Hg and U-Hg is approximately linear. K-Hg can be estimated using U-Hg and gender. Women have longer half-time of Hg in kidney compared to men. Adjusting overnight urine samples for creatinine concentration resulted in less bias.
Journal: Toxicology and Applied Pharmacology - Volume 320, 1 April 2017, Pages 17-25