کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5558967 1561232 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulation of endothelial homeostasis, vascular development and angiogenesis by the transcription factor ERG
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Regulation of endothelial homeostasis, vascular development and angiogenesis by the transcription factor ERG
چکیده انگلیسی

Over the last few years, the ETS transcription factor ERG has emerged as a major regulator of endothelial function. Multiple studies have shown that ERG plays a crucial role in promoting angiogenesis and vascular stability during development and after birth. In the mature vasculature ERG also functions to maintain endothelial homeostasis, by transactivating genes involved in key endothelial functions, while repressing expression of pro-inflammatory genes. Its homeostatic role is lineage-specific, since ectopic expression of ERG in non-endothelial tissues such as prostate is detrimental and contributes to oncogenesis. This review summarises the main roles and pathways controlled by ERG in the vascular endothelium, its transcriptional targets and its functional partners and the emerging evidence on the pathways regulating ERG's activity and expression.

ERG regulation of endothelial function and homeostasis.142

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vascular Pharmacology - Volume 86, November 2016, Pages 3-13
نویسندگان
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