کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5561228 | 1562120 | 2017 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The chronic hepatotoxicity assessment of the herbal formula Zishen Yutai pill The chronic hepatotoxicity assessment of the herbal formula Zishen Yutai pill](/preview/png/5561228.png)
- The liver toxicity of ZYP was assessed in both normal and the CCl4 induced chronic liver injury rats.
- No any mortality or abnormality in liver toxicity evaluation were noted in ZYP groups.
- No solid evidence of liver toxicity under ZYP exposure (9.450 g kgâ1 dâ1) was found.
Zishen Yutai pill (ZYP) is an oriental herbal formula, while hepatotoxicity assessment of ZYP was rarely evaluated. Therefore, our aim is to re-evaluate its hepatotoxicity in both normal and carbon tetrachloride (CCl4) induced chronic liver injury rats. In the normal model, two doses of ZYP (1.575 and 9.450 g kgâ1 dâ1; i.e. 1 Ã , 6 Ã clinical doses) were given orally to rats for 24 weeks. In the chronic liver injury model, 10% CCl4 was administered to rats abdominally twice a week at a dose of 5 mL kgâ1 for 12 consecutive weeks. Administration time started from 4 weeks after the beginning of CCl4 treatment. Toxicological parameters included mortality, body weight, food consumption, clinical signs, biochemical parameters, gross observation, organ weight, necropsy findings and histopathology were monitored. In the normal model, we found no any mortality or abnormality in clinical signs, relative liver weight, biochemical parameters and histopathology in ZYP treatment groups. In the chronic liver injury model, liver damage related parameter such as ALT was elevated at the high dose of ZYP treatment in contrast to the CCl4-treated group (P < 0.01). In histopathological assessment, there were no significant difference between ZYP treatment groups and CCl4-treated group. No observed adverse effect on livers were established for 9.450 g kgâ1 dâ1 ZYP in the normal rats and 9.450 g kgâ1 dâ1 ZYP in the injury rats.
Journal: Regulatory Toxicology and Pharmacology - Volume 83, February 2017, Pages 81-88