کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5561399 | 1562119 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of pre and post-treatments with dipyridamole in gentamicin-induced acute nephrotoxicity in the rat
ترجمه فارسی عنوان
اثرات پیش و پس از درمان با دیپیریدامول در نارسایی مزمن حاد ناشی از جنتامایسین در موش صحرایی
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کلمات کلیدی
جنتامایسین، نفخ عصبی حاد، اختلال عملکرد کلیه، التهاب کلیه، دیپیریدامول، حفاظت مجدد
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
This study investigated the pretreatment and post-treatment effects of dipyridamole (20Â mg/kg/day, p.o.) in gentamicin-induced acute nephrotoxicity in rats. Rats were administered gentamicin (100Â mg/kg/day, i.p.) for 8 days. Gentamicin-administered rats exhibited renal structural and functional changes as assessed in terms of a significant increase in serum creatinine and urea and kidney weight to body weight ratio as compared to normal rats. Renal histopathological studies revealed a marked incidence of acute tubular necrosis in gentamicin-administered rats. These renal structural and functional abnormalities in gentamicin-administered rats were accompanied with elevated serum uric acid level, and renal inflammation as assessed in terms of decrease in interleukin-10 levels. Dipyridamole pretreatment in gentamicin-administered rats afforded a noticeable renoprotection by markedly preventing renal structural and functional abnormalities, renal inflammation and serum uric acid elevation. On the other hand, dipyridamole post-treatment did not significantly prevent uric acid elevation and renal inflammation, and resulted in comparatively less protection on renal function although it markedly reduced the incidence of tubular necrosis. In conclusion, uric acid elevation and renal inflammation could play key roles in gentamicin-nephrotoxicity. Dipyridamole pretreatment markedly prevented gentamicin-induced acute nephrotoxicity, while its post-treatment resulted in comparatively less renal functional protection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 84, March 2017, Pages 35-44
Journal: Regulatory Toxicology and Pharmacology - Volume 84, March 2017, Pages 35-44
نویسندگان
Pitchai Balakumar, Wei Ern WitnessKoe, Yi Syen Gan, Soo Mei JemayPuah, Subramaniam Kuganesswari, Sunil Kumar Prajapati, Rajavel Varatharajan, Sam Annie Jayachristy, Karupiah Sundram, Mohd Baidi Bahari,