Polycyclic aromatic hydrocarbons and female reproductive health: A scoping review

- The breadth of research of the effects of PAHs on female reproduction was reviewed.
- Feasible endpoints for future systematic review were determined.
- Best endpoints for systematic review were fertility and pregnancy/fetal viability.
- Review highlights the need for noncancer systematic reviews of PAH health effects.
- Mechanistic studies may support potential impacts of PAHs on female reproduction.

Polycyclic aromatic hydrocarbons (PAHs) are a class of common persistent environmental pollutants found in water, air, soil, and plants and can be released by natural sources. However, the majority of atmospheric PAHs are from vehicular emissions, coal-burning plants, and the production and use of petroleum-derived substances. Exposure to PAHs has been implicated in cancer and other diseases, including reproductive disorders. This scoping review is a preliminary step that explores the utility and feasibility of completing a systematic review evaluating the effect of PAHs on female reproduction. We performed literature searches in PubMed, Web of Science, and Scopus, then screened, identified, and categorized relevant studies. Our results identified fertility and pregnancy/fetal viability as outcomes with sufficient research for systematic review. In addition to presenting the relevant studies, the review identifies data gaps, and provides the groundwork to develop the most appropriate research questions for systematic review.