کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5561654 | 1562152 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Second trimester amniotic fluid bisphenol A concentration is associated with decreased birth weight in term infants
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کلمات کلیدی
BPASRMMQCEDCPFBLOQBisphenol A - بیسفنول ای، بیسفنول ALOD یا Limit of detection - حد تشخیصIn utero exposure - در معرض رحمDevelopmental origins of health and disease - ریشه های رشد سلامت و بیماریgestational age - سن حاملگیendocrine disrupting chemical - شیمیایی خرابکار غدد درون ریزamniotic fluid - مایع آمنیوتیکlimit of quantification - محدودیت اندازه گیریlimit of detection - محدودیت تشخیصselected reaction monitoring - نظارت بر واکنش انتخاب شدهPentafluorobenzyl - پنتافلوئوروبرنسیل
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Bisphenol A (BPA) is an endocrine disrupting chemical with ubiquitous environmental exposure. Animal studies have demonstrated that in utero BPA exposure leads to increased adult body weight. Our aim was to characterize human fetal BPA exposure by measuring BPA concentration in second trimester amniotic fluid (AF) samples and to study its relationship with birth weight (BW) in full term infants. To achieve these goals, we developed a total BPA assay utilizing derivatization with pentafluorobenzyl followed by analysis with LC-ECAPCI-MS/MS with a limit of detection of 0.08 ng/mL and limit of quantification (LOQ) of 0.25 ng/mL. The mean BW of infants with AF BPA 0.40-2.0 ng/mL was 241.8 g less than infants with AF BPA less than the LOQ after controlling for covariates (p = 0.049). No effect was seen outside this range indicating a non-monotonic effect. Our data suggest that low level BPA exposure in utero decreases BW and needs further study.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 67, January 2017, Pages 1-9
Journal: Reproductive Toxicology - Volume 67, January 2017, Pages 1-9
نویسندگان
Sara E. Pinney, Clementina A. Mesaros, Nathaniel W. Snyder, Christine M. Busch, Rui Xiao, Sara Aijaz, Naila Ijaz, Ian A. Blair, Jeanne M. Manson,