کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5562068 1562594 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Remodeling of brain lipidome in methamphetamine-sensitized mice
ترجمه فارسی عنوان
بازسازی چربی لیدیوم در موش های حساس شده با متامفتامین
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


- Hippocampus, PFC and striatum are the three brain regions preferentially affected by METH.
- Repeated methamphetamine exposure profoundly modifies phospholipids (PLs), sphingolipids (SLs) and glycerolipids (GLs) metabolism.
- METH alters the composition of fatty acyl of global brain.

Lipids are predominant components of the brain and key regulators for neural structure and function. The effect of methamphetamine (METH) on behavior, cognition as well as memory has been intensively investigated; however, the impact of METH on brain lipid profiles is largely unknown. Here, we used a global lipidomic approach to investigate brain lipidome of METH-sensitized mice. We found that repeated METH significantly modified the lipidome in the hippocampus, prefrontal cortex (PFC) and striatum. Interestingly, nucleus accumbens showed no obvious alteration in lipidomic profiling. Phospholipid and sphingolipid metabolisms were profoundly modified in the hippocampus of METH-sensitized mice, exhibiting increased phosphatidic acid and ether phosphatidylcholine but decreased lysophosphatidylethanolamine, lactosylceramide and triglycerides. The fatty acyl length of phospholipids and diacylglycerol longer than 40 carbon were clearly decreased in the hippocampus, and that 36 carbon was decreased in the PFC. These results indicate METH can profoundly affect the metabolism of phospholipids, sphingolipids and glycerolipids in the brain. Our findings reveal a link between remodeled brain lipidome and neurobehavior induced by METH.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 279, 5 September 2017, Pages 67-76
نویسندگان
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