کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5562080 | 1562599 | 2017 | 11 صفحه PDF | دانلود رایگان |
- Chrysotile, crocidolite and erionite fibres inoculated in rats are studied with synchrotron μ-XRD and HR-TEM.
- Chrysotile asbestos is not stable within the tissues of the rats, forming a fibrous silica pseudo-morph.
- Crocidolite and erionite fibres are stable even for very long contact times within the tissues of the rats.
- A silica rich thin amorphous halo forms around crocidolite and erionite fibres for long contact times in the rats.
- The nature of the silica rich dissolution product of chrysotile may explain the toxicity of this fibre.
Along the line of the recent research topic aimed at understanding the in vivo activity of mineral fibres and their mechanisms of toxicity, this work describes the morpho-chemical characteristics of the mineral fibres found in the tissues of Sprague-Dawley rats subjected to intraperitoneal/intrapleural injection of UICC chrysotile, UICC crocidolite and erionite-Na from Nevada (USA). The fibres are studied with in situ synchrotron powder diffraction and high resolution transmission electron microscopy to improve our understanding of the mechanisms of toxicity of these mineral fibres. In contact with the tissues of the rats, chrysotile fibres are prone to dissolve, with leaching of Mg and production of a silica rich relict. On the other hand, crocidolite and erionite-Na fibres are stable even for very long contact times within the tissues of the rats, showing just a thin dissolution amorphous halo. These findings support the model of a lower biopersistence of chrysotile with respect to crocidolite and erionite-Na but the formation of a silica-rich fibrous residue after the pseudo-amorphization of chrysotile may justify a higher cytotoxic potential and intense inflammatory activity of chrysotile in the short term in contact with the lung tissues.
Journal: Toxicology Letters - Volume 274, 15 May 2017, Pages 20-30