A study on the in vitro percutaneous absorption of silver nanoparticles in combination with aluminum chloride, methyl paraben or di-n-butyl phthalate

The inductively coupled plasma mass spectrometry (ICP-MS) measurements after 24 h in receptor fluid indicated low, but detectable silver absorption and no statistically significant differences in the penetration between the 4 types of AgNP studied at 47, 470 or 750 μg/ml. Similarly, no significant differences were observed for silver penetration when the AgNP were used in combinations with AlCl3 (500 μM), MPB (1250 μM) or DBPH (35 μM). The measured highest amount of Ag that penetrated was 0.45 ng/cm2 (0.365-0.974 ng/cm2) for PEG stabilized Ag15 nm + MPB.