کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5562556 1562701 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
SAMPA: A free software tool for skin and membrane permeation data analysis
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
SAMPA: A free software tool for skin and membrane permeation data analysis
چکیده انگلیسی


- software tool for Skin And Membrane Permeation data Analysis, SAMPA
- an automated and objective method for estimation of the flux and lag time reduces variability
- validated on in vitro human and pig skin and model membranes and in vivo rat skin
- user-friendly software, available as a Supporting file to this article

Skin and membrane permeation experiments comprise an important step in the development of a transdermal or topical formulation or toxicological risk assessment. The standard method for analyzing these data relies on the linear part of a permeation profile. However, it is difficult to objectively determine when the profile becomes linear, or the experiment duration may be insufficient to reach a maximum or steady state. Here, we present a software tool for Skin And Membrane Permeation data Analysis, SAMPA, that is easy to use and overcomes several of these difficulties. The SAMPA method and software have been validated on in vitro and in vivo permeation data on human, pig and rat skin and model stratum corneum lipid membranes using compounds that range from highly lipophilic polycyclic aromatic hydrocarbons to highly hydrophilic antiviral drug, with and without two permeation enhancers. The SAMPA performance was compared with the standard method using a linear part of the permeation profile and a complex mathematical model. SAMPA is a user-friendly, open-source software tool for analyzing the data obtained from skin and membrane permeation experiments. It runs on a Microsoft Windows platform and is freely available as a Supporting file to this article.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 44, October 2017, Pages 361-371
نویسندگان
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