کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5562586 1562702 2017 33 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluating a novel oxygenating therapeutic for its potential use in the advancement of wound healing
ترجمه فارسی عنوان
ارزیابی یک درمان با اکسیژن دهنده جدید برای استفاده بالقوه در پیشرفت بهبود زخم
کلمات کلیدی
التیام زخم، اکسیژن موضعی موضعی، اکسیژن، فیبروبلاست، کراتینوسیت، میکروسکوپ الکترونی اسکن،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Non-gaseous oxygen therapeutics are emerging technologies in regenerative medicine that aim to sidestep the undesirable effects seen in traditional oxygen therapies, while enhancing tissue and wound regeneration. Using a novel oxygenating therapeutic (Ox66™) several in vitro models including fibroblast and keratinocyte monocultures were evaluated for potential drug toxicity, the ability of cells to recover after chemical injury, and cell migration after scratch assay. It was determined that in both cell lines, there was no significant cytotoxicity found after independent treatment with Ox66™. Similarly, after DMSO-induced chemical injury, the health parameters of cells treated with Ox66™ were improved when compared to their untreated counterparts. Particles were also characterized using scanning electron microscopy and electron dispersive spectroscopy both individually and in conjunction with fibroblast growth. The data in this study showed that the novel wound healing therapeutic has potential in advancing the treatment of various types of acute and chronic wounds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 43, September 2017, Pages 62-68
نویسندگان
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