کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5562759 1562707 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impact of cerium oxide nanoparticles shape on their in vitro cellular toxicity
ترجمه فارسی عنوان
تاثیر نانوذرات اکسید سریم بر روی سمیت سلولی ویروسی آنها
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


- Investigation of the impact of CeO2 nanoparticles shape on their in vitro toxicity.
- Macrophages exposed to rod or octahedron/cube CeO2 nanoparticles.
- LDH release and TNF-α production significantly enhanced by rod-like nanoparticles.
- But not with cubic/octahedral nanoparticles
- Strong impact of CeO2 nanoparticle shape on their in vitro toxicity.

Cerium oxides (CeO2) nanoparticles, also referred to as nanoceria, are extensively used with a wide range of applications. However, their impact on human health and on the environment is not fully elucidated. The aim of this study was to investigate the influence of the CeO2 nanoparticles morphology on their in vitro toxicity. CeO2 nanoparticles of similar chemical composition and crystallinity were synthesized, only the shape varied (rods or octahedrons/cubes). Macrophages from the RAW264.7 cell line were exposed to these different samples and the toxicity was evaluated in terms of lactate dehydrogenase (LDH) release, Tumor Necrosis Factor alpha (TNF-α) production and reactive oxygen species (ROS) generation. Results showed no ROS production, whatever the nanoparticle shape. The LDH release and the TNF-α production were significantly and dose-dependently enhanced by rod-like nanoparticles, whereas they did not vary with cubic/octahedral nanoparticles. In conclusion, a strong impact of CeO2 nanoparticle morphology on their in vitro toxicity was clearly demonstrated, underscoring that nanoceria shape should be carefully taken in consideration, especially in a “safer by design” context.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 38, February 2017, Pages 136-141
نویسندگان
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