کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5567874 | 1403657 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Long-term effectiveness and safety of once-daily, single-entity, extended-release hydrocodone in patients of â¥75 years of age with moderate to severe nonmalignant and nonneuropathic pain
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
طب سالمندان و علم پیری شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Long-term effectiveness and safety of once-daily, single-entity, extended-release hydrocodone in patients of â¥75 years of age with moderate to severe nonmalignant and nonneuropathic pain Long-term effectiveness and safety of once-daily, single-entity, extended-release hydrocodone in patients of â¥75 years of age with moderate to severe nonmalignant and nonneuropathic pain](/preview/png/5567874.png)
چکیده انگلیسی
In elderly (â¥75 years) individuals, age-associated physiologic changes and a higher prevalence of comorbidities, polypharmacy, and increased susceptibility to medication-induced side effects complicate pain management. Hysingla® ER (HYD) is a once-daily, single-entity, extended-release hydrocodone formulation approved for the treatment of chronic pain that is insufficiently controlled by alternative treatments. In this post-hoc analysis of a previously reported study, the effectiveness and safety of HYD for the treatment of moderate-to-severe chronic pain among the elderly (â¥75 years) for a 52-week duration was investigated. HYD dose administered during the maintenance period-remained relatively stable and provided clinically meaningful decreases in mean “pain over the last 24 h” and pain interference scores. Patients achieved pain control without additional non-study opioid use at the end of the study. Adverse events were typical of opioids. In summary, HYD provided clinically meaningful reduction of pain scores in elderly patients that were maintained over a 52-week period.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Geriatric Nursing - Volume 38, Issue 1, JanuaryâFebruary 2017, Pages 39-47
Journal: Geriatric Nursing - Volume 38, Issue 1, JanuaryâFebruary 2017, Pages 39-47
نویسندگان
Kathleen DNP, Joseph MD, Maribeth PharmD, Shau Yu PhD, Ellie PhD, Warren PhD,