کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5585278 1568116 2017 31 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Statistical analysis of the inter-individual variations of the bone shape, volume fraction and fabric and their correlations in the proximal femur
ترجمه فارسی عنوان
تجزیه و تحلیل آماری تغییرات بین فردی شکل استخوانی، کسر حجم و پارچه و همبستگی آنها در فک پایین پروگزیمال
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موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
چکیده انگلیسی
Including structural information of trabecular bone improves the prediction of bone strength and fracture risk. However, this information is available in clinical CT scans, only for peripheral bones. We hypothesized that a correlation exists between the shape of the bone, its volume fraction (BV/TV) and fabric, which could be characterized using statistical modeling. High-resolution peripheral computed tomography (HR-pQCT) images of 73 proximal femurs were used to build a combined statistical model of shape, BV/TV and fabric. The model was based on correspondence established by image registration and by morphing of a finite element mesh describing the spatial distribution of the bone properties. Results showed no correlation between the distribution of bone shape, BV/TV and fabric. Only the first mode of variation associated with density and orientation showed a strong relationship (R2 > 0.8). In addition, the model showed that the anisotropic information of the proximal femur does not vary significantly in a population of healthy, osteoporotic and osteopenic samples. In our dataset, the average anisotropy of the population was able to provide a close approximation of the patient-specific anisotropy. These results were confirmed by homogenized finite element (hFE) analyses, which showed that the biomechanical behavior of the proximal femur was not significantly different when the average anisotropic information of the population was used instead of patient-specific fabric extracted from HR-pQCT. Based on these findings, it can be assumed that the fabric information of the proximal femur follows a similar structure in an elderly population of healthy, osteopenic and osteoporotic proximal femurs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 103, October 2017, Pages 252-261
نویسندگان
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