کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5588588 | 1569106 | 2017 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Increased naive CD4+ and B lymphocyte subsets are associated with body mass loss and drive relative lymphocytosis in anorexia nervosa patients
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کلمات کلیدی
CD45RA+CD45RO+Body mass lossDSMANPWBCANRCD3+natural killer - (سلول های) کشنده طبیعیCD4+ - CD4 +CD8+ - CD8 +Eating disorder - اختلال خوردنAnorexia nervosa - بیاشتهایی عصبیanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceDiagnostic and Statistical Manual of Mental Disorders - راهنمای تشخیصی و آماری اختلالهای روانیLymphocyte subsets - زیر مجموعه های لنفوسیتhelper T cells - سلول T کمکیB cells - سلول های Bcytotoxic T cells - سلول های T سیتوتوکسیکmemory cells - سلول های حافظهNatural killer cells - سلولهای کشنده طبیعیbody mass index - شاخص توده بدنBMI - شاخص توده بدنیwhite blood cell - گلبول سفید خونwhite blood cells - گلبول های سفید خون
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Increased naive CD4+ and B lymphocyte subsets are associated with body mass loss and drive relative lymphocytosis in anorexia nervosa patients Increased naive CD4+ and B lymphocyte subsets are associated with body mass loss and drive relative lymphocytosis in anorexia nervosa patients](/preview/png/5588588.png)
چکیده انگلیسی
Anorexia nervosa (AN) is an atypical form of malnutrition with peculiar changes in the immune system. We hypothesized that different lymphocyte subsets are differentially affected by malnutrition in AN, and thus, our aim was to investigate the influence of body mass loss on the variability of lymphocyte subsets in AN patients. A group of 66 adolescent female patients, aged 12-17 years, referred for their first episode of either AN or feeding or eating disorders not elsewhere classified were studied upon admission (46 AN-restricting subtype, 11 AN-binge/purging subtype, and 9 feeding or eating disorders not elsewhere classified). Ninety healthy adolescents served as controls. White blood cells and lymphocyte subsets were analyzed by flow cytometry. Relationships with the body mass index (BMI) z score were assessed in linear models adjusted by diagnostic subtype and age. Leukocyte numbers were lower in AN patients than in controls, and relative lymphocytosis was observed in AN-restricting subtype. Lower CD8+, NK, and memory CD8+ counts were found in eating disorder patients compared with controls. No differences were found for CD4+ counts or naive and memory CD4+ subsets between the groups. Negative associations between lymphocyte percentage and the BMI z score, as well as between the B cell counts, naive CD4+ percentage and counts, and the BMI z score, were found. In conclusion, increased naive CD4+ and B lymphocyte subsets associated with body mass loss drive the relative lymphocytosis observed in AN patients, which reflects an adaptive mechanism to preserve the adaptive immune response.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition Research - Volume 39, March 2017, Pages 43-50
Journal: Nutrition Research - Volume 39, March 2017, Pages 43-50
نویسندگان
Ana Elegido, Montserrat Graell, Patricia Andrés, Alina Gheorghe, Ascensión Marcos, Esther Nova,