کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5615384 1405968 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Severe decrease in high-density lipoprotein cholesterol with the combination of fibrates and ezetimibe: A case series
ترجمه فارسی عنوان
کاهش شدید کلسترول لیپوپروتئین با چگالی بالا با ترکیب فیبرها و ایزتییب: یک سری موارد
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
A sudden and severe drug-induced decrease in plasma high-density lipoprotein cholesterol (HDL-C) is a rare condition. We report 2 patients with familial hypercholesterolemia treated with statins and fibrates and 2 others with mixed dyslipidemia treated with fibrates, who presented with a sudden and severe decrease in HDL-C (from −44% to −95%, compared with baseline). Three of the patients were treated with fibrates and had a sudden decrease in HDL-C after the adjunction of ezetimibe. HDL-C returned to normal levels after discontinuation of the offending therapies. In 2 of these patients, the reintroduction of ezetimibe with no fibrates did not affect HDL-C. In conclusion, we report a new profile of patients who are at risk for a sudden drop of HDL-C related to treatment with a combination of fibrates and ezetimibe. Although a sudden drop of HDL-C is a rare event, we recommend to carefully monitor plasma HDL-C in patients submitted to both drugs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Lipidology - Volume 11, Issue 1, January–February 2017, Pages 289-293
نویسندگان
, , , , , , ,