کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5619075 1406052 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Carotid plaque instability is not related to quantity but to elemental composition of calcification
ترجمه فارسی عنوان
بی ثباتی پلاک کاروتید نسبت به مقدار نیست، بلکه ترکیب عنصری کلسیفیکاسیون است
کلمات کلیدی
بیماری قلب و عروقی، آترواسکلروز، کلسیفیکاسیون پلاک، هیدروکسی آپاتیت، میکروسکوپ اشعه ایکس پراکنده انرژی،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی


- Calcified plaques are composed of two types of calcium, hydroxyapatite ad calcium oxalate.
- Calcium oxalate was frequently found in stable plaques.
- Hydroxyapatite was present in both stable and unstable plaque.
- The presence of hydroxyapatite could be related to activity of cells with osteoblast phenotype.

Background and aimsRecent studies highlighted the role of calcification processes in the clinical progression of chronic cardiovascular diseases. In this study we investigated the relationship between the chemical composition of calcification and atherosclerotic plaque stability in carotid arteries.Methods and resultsTo this end, we characterized the calcification on 229 carotid plaques, by morphology, immunohistochemistry, transmission electron microscopy and energy dispersive X-ray microanalysis. Plaques were classified into two categories: unstable and stable. No significant differences were found in the incidence of the various risk factors between patients with and without carotid calcification, with the exception of diabetes. The energy dispersive X-ray microanalysis allowed us to identify two types of calcium salts in the atheromatous plaques, hydroxyapatite (HA) and calcium oxalate (CO). Our results showed that calcification is a common finding in carotid plaques, being present in 77.3% of cases, and the amount of calcium is not a factor of vulnerability. Noteworthy, we observed an association between HA calcification and unstable plaques. On the contrary, CO calcifications were mainly detected in stable plaques.ConclusionsThe presence of different types of calcification in atheromatous plaques may open new perspectives in understanding the molecular mechanisms of atheroma formation and plaque instability.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition, Metabolism and Cardiovascular Diseases - Volume 27, Issue 9, September 2017, Pages 768-774
نویسندگان
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