کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5623001 1406195 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Short ReportThe ε4 genotype of apolipoprotein E and white matter integrity in Alzheimer's disease
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Short ReportThe ε4 genotype of apolipoprotein E and white matter integrity in Alzheimer's disease
چکیده انگلیسی

BackgroundIn this multicenter study, we investigated a possible association between the APOE ε4 allele and white matter (WM) integrity in Alzheimer's disease (AD) using diffusion tensor imaging (DTI).MethodsWe analyzed fractional anisotropy (FA) and mean diffusivity (MD) as indices of WM integrity in 70 AD patients (35 APOE ε4 carriers, 35 noncarriers) and 56 healthy control (HC) subjects (28 APOE ε4 carriers, 28 noncarriers). APOE ε4 carriers and noncarriers were matched for age and gender within each diagnostic group.ResultsWe found significant effects of diagnosis (Pcorrected < .05 [FWE]; i.e., smaller FA values and larger MD values in AD patients compared with HCs) and significant effects (P < .001) of APOE ε4 carrier status on MD in HCs but not in AD subjects.ConclusionsThe results indicate that APOE ε4 has a moderate effect on WM integrity in HCs, but no effect on WM integrity in manifest AD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia - Volume 10, Issue 3, May 2014, Pages 401-404
نویسندگان
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