کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5623435 | 1406208 | 2008 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Featured articleOne-week dose titration of extended release galantamine in patients with Alzheimer's disease Featured articleOne-week dose titration of extended release galantamine in patients with Alzheimer's disease](/preview/png/5623435.png)
BackgroundOur purpose was to assess the safety and tolerability of extended-release galantamine (GAL-ER), using a 1-week dose titration in Alzheimer's patients.MethodsAn open-label, 12-week, multicenter study was performed (n = 82). Results were compared with findings from a placebo-controlled trial using a 4-week titration of GAL-ER and immediate-release galantamine. The primary analysis compared incidences of adverse events (AEs).ResultsAlthough not statistically significant, more patients in the 1-week titration study experienced an AE. More patients with a 1-week titration had at least one prespecified gastrointestinal (GI) AE. These findings correlated with a higher baseline incidence of GI disturbances. Four patients experienced serious AEs; no deaths occurred. Mean Mini-Mental State Examination scores improved by 1.8 and 1.9 points at weeks 4 and 12, respectively.ConclusionsA 1-week titration of GAL-ER was generally safe and well tolerated, with a potential risk of more GI side effects. A 1-week titration may permit dosing flexibility and promote increased adherence to medication regimens.
Journal: Alzheimer's & Dementia - Volume 4, Issue 1, January 2008, Pages 30-37