کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5623666 1406217 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Featured ArticleMixed neuropathologies and estimated rates of clinical progression in a large autopsy sample
ترجمه فارسی عنوان
عوارض جانبی مرتبط با مادهای غیرمعمول و میزان بروز پیشرفت بالینی در یک نمونه بزرگ شکم
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی

IntroductionWhether co-occurring neuropathologies interact or independently affect clinical disease progression is uncertain. We estimated rates of clinical progression and tested whether associations between clinical progression and Alzheimer's disease neuropathology (ADNP) were modified by co-occurring Lewy body disease (LBD) or vascular brain injury (VBI).MethodsLinear mixed effects models evaluated longitudinal trends in the Clinical Dementia Rating Scale Sum of Boxes on 2046 autopsied participants seen at a U.S. Alzheimer's Disease Center.ResultsAnnual clinical progression was slightly faster for ADNP + LBD compared with ADNP only (P = .06) and slightly slower for ADNP + VBI (P = .003). Differences in progression were less than expected if each neuropathology independently contributed to progression; ADNP interacted with LBD (P = .002) and VBI (P = .003). In secondary models, the effect of additional pathologies on clinical progression was greater in those with intermediate compared with high levels of ADNP.DiscussionThe impact of co-occurring pathologies on progression may depend on severity of ADNP.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia - Volume 13, Issue 6, June 2017, Pages 654-662
نویسندگان
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