کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5623755 | 1406222 | 2017 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Featured ArticleTract-specific white matter hyperintensities disrupt neural network function in Alzheimer's disease Featured ArticleTract-specific white matter hyperintensities disrupt neural network function in Alzheimer's disease](/preview/png/5623755.png)
IntroductionWhite matter hyperintensities (WMHs) increase the risk of Alzheimer's disease (AD). Whether WMHs are associated with the decline of functional neural networks in AD is debated.MethodResting-state functional magnetic resonance imaging and WMH were assessed in 78 subjects with increased amyloid levels on AV-45 positron emission tomography (PET) in different clinical stages of AD. We tested the association between WMH volume in major atlas-based fiber tract regions of interest (ROIs) and changes in functional connectivity (FC) between the tracts' projection areas within the default mode network (DMN).ResultsWMH volume within the inferior fronto-occipital fasciculus (IFOF) was the highest among all tract ROIs and associated with reduced FC in IFOF-connected DMN areas, independently of global AV-45 PET. Higher AV-45 PET contributed to reduced FC in IFOF-connected, temporal, and parietal DMN areas.ConclusionsHigh fiber tract WMH burden is associated with reduced FC in connected areas, thus adding to the effects of amyloid pathology on neuronal network function.
Journal: Alzheimer's & Dementia - Volume 13, Issue 3, March 2017, Pages 225-235