کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5623758 1406222 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Featured ArticleAn investigation of cerebrovascular lesions in dementia with Lewy bodies compared to Alzheimer's disease
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Featured ArticleAn investigation of cerebrovascular lesions in dementia with Lewy bodies compared to Alzheimer's disease
چکیده انگلیسی

IntroductionCerebrovascular lesions on MRI are common in Alzheimer's disease (AD) dementia, but less is known about their frequency and impact on dementia with Lewy bodies (DLB).MethodsWhite-matter hyperintensities (WMHs) and infarcts on MRI were assessed in consecutive DLB (n = 81) and AD dementia (n = 240) patients and compared to age-matched and sex-matched cognitively normal subjects (CN) from a population-based cohort.ResultsDLB had higher WMH volume compared to CN, and WMH volume was higher in the occipital and posterior periventricular regions in DLB compared to AD. Higher WMH volume was associated with history of cardiovascular disease and diabetes but not with clinical disease severity in DLB. Frequency of infarcts in DLB was not different from CN and AD dementia.DiscussionIn DLB, WMH volume is higher than AD and CN and appears to be primarily associated with history of vascular disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia - Volume 13, Issue 3, March 2017, Pages 257-266
نویسندگان
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