کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5626944 1579662 2017 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Monthly methylprednisolone in combination with interferon beta or glatiramer acetate for relapsing-remitting multiple sclerosis: A multicentre, single-blind, prospective trial
ترجمه فارسی عنوان
متیل پردنیزولون ماهانه همراه با اینترفرون بتا یا گتیمایمر استات برای بیمار مبتلا به مولتیپل اسکلروزیس مجدد: چندین مرکز، تک کور، آزمایش آینده نگر
کلمات کلیدی
ریفلاکس مجدد مولتیپل اسکلروزیس، پالس متیل پردنیزولون، مقیاس وضعیت بیماری گسترش یافته، معلولیت،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


- This study shows that the addition of monthly IVMP to DMD significantly reduced relapse rates in RRMS patients.
- In addition, these combinations were also safe, and most patients tolerated methylprednisolone as an add-on to DMD.
- Monthly IVMP as an add-on therapy to interferon beta or GA seems to be safe and potentially useful.
- Monthly IVMP may be alternative for more expensive and potentially more harmful therapies for patients with RRMS.

ObjectivesMultiple sclerosis is usually clinically characterized by repeated subacute relapses followed by remissions. Corticosteroids are used for relapses, and this treatment has been shown to increase the speed of recovery from these. We aimed to evaluate the efficacy and safety of pulsed methylprednisolone given every month as an add-on therapy to interferon beta or glatiramer acetate in patients with relapsing-remitting multiple sclerosis.Patients and methodsThis was a multi-center, examiner-blinded, prospective study. Absolute annualized relapse rates and Expanded Disability Status Scale scores were calculated.Results103 patients were given intravenous methylprednisolone (1 dose of 1 g IV) once a month for 12 months as add-on therapy and were assessed during this period. The decrease in the absolute annualized relapse rate was 0.69, and 72 patients were relapse-free at the end of the year. Sixty-nine of the 103 patients had the same Expanded Disability Status Scale scores at the end of one year, while 21 were less disabled, and 13 sustained disability progression. Health related quality of life measured using the MS Quality of Life scale improved significantly during the study period.ConclusionThe addition of monthly pulsed methylprednisolone to subcutaneous interferon beta or glatiramer acetate therapy significantly reduced the relapse rate and may also be beneficial in terms of disease progression. These combinations were also safe, and most patients tolerated methylprednisolone as an add-on to interferon beta or glatiramer acetate.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurology and Neurosurgery - Volume 160, September 2017, Pages 69-72
نویسندگان
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