کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5627167 1579669 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Does preoperative oral carbohydrate treatment reduce the postoperative surgical stress response in lumbar disc surgery?
ترجمه فارسی عنوان
آیا درمان کربوهیدرات خوراکی قبل از عمل باعث کاهش پاسخ استرس پس از عمل جراحی در جراحی دیسک کمر می شود؟
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


- Extension of the preoperative fasting period increases the magnitude of postoperative insulin resistance.
- The use of POC treatment in patients undergoing lumbar disc surgery did not attenuate the development of insulin resistance.
- The lack of insulin resistance may be associated with minimal development of insulin resistance following lumbar disc surgery.

ObjectivesSurgical trauma produces metabolic and hormonal responses, which are characterized by insulin resistance. Due to extension of the preoperative fasting period, which increases the magnitude of postoperative insulin resistance, preoperative oral carbohydrates (POC) have been developed.Patients and methodsThis prospective, randomized, controlled study was performed on 43 ASA I-II patients undergoing elective microsurgical lumbar discectomy. The intervention group received oral carbohydrate solution 800 mL the night before and 400 mL 2 h prior to operation. The other group fasted for 8 h prior to operation. Blood samples were obtained the day before the operation, before induction of anesthesia, after skin incision, 1 h, 2 h, 6 h and 24 h following skin incision. Blood glucose, plasma insulin, cortisol and interleukin-6 (IL-6) levels were determined. The primary endpoint was to assess the effect of POC treatment on insulin resistance and surgical stress response following lumbar disc surgery. The secondary endpoint was to assess POC's effects on postoperative nausea and vomiting.ResultsThe serum insulin levels were higher before induction of anesthesia in the study group and returned to fasted group levels by 2 h after skin incision. The plasma IL-6 levels were higher in the intervention group at 6 h after the skin incision. There were no differences between the two groups with respect to blood glucose, plasma cortisol levels and the incidence of nausea and vomiting.ConclusionThis study suggests that use of POC treatment does not attenuate development of insulin resistance in patients undergoing lumbar disc surgery.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurology and Neurosurgery - Volume 153, February 2017, Pages 82-86
نویسندگان
, , , , ,