کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5627987 1579822 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cannabis cultivation: Methodological issues for obtaining medical-grade product
ترجمه فارسی عنوان
کشت مواد مخدر: مسائل متدولوژیک برای دستیابی به محصول کالای پزشکی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


- Best practices for large-scale phytopharmaceutical production of Cannabis are needed.
- Success of GW Pharm and University of Mississippi with Cannabis crops is described.
- GW Pharmaceuticals has chemotypes dominant in any one of eight cannabinoids.
- UM has had success with direct organogenesis-regenerated Cannabis plants.
- These protocols can be used in phytopharmaceutical Cannabis research and propagation.

As studies continue to reveal favorable findings for the use of cannabidiol in the management of childhood epilepsy syndromes and other disorders, best practices for the large-scale production of Cannabis are needed for timely product development and research purposes. The processes of two institutions with extensive experience in producing large-scale cannabidiol chemotype Cannabis crops-GW Pharmaceuticals and the University of Mississippi-are described, including breeding, indoor and outdoor growing, harvesting, and extraction methods. Such practices have yielded desirable outcomes in Cannabis breeding and production: GW Pharmaceuticals has a collection of chemotypes dominant in any one of eight cannabinoids, two of which-cannabidiol and cannabidivarin-are supporting epilepsy clinical trial research, whereas in addition to a germplasm bank of high-THC, high-CBD, and intermediate type cannabis varieties, the team at University of Mississippi has established an in vitro propagation protocol for cannabis with no detectable variations in morphologic, physiologic, biochemical, and genetic profiles as compared to the mother plants. Improvements in phytocannabinoid yields and growing efficiency are expected as research continues at these institutions.This article is part of a Special Issue entitled “Cannabinoids and Epilepsy”.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 70, Part B, May 2017, Pages 302-312
نویسندگان
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