کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5628312 1406370 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Localized shape abnormalities in the thalamus and pallidum are associated with secondarily generalized seizures in mesial temporal lobe epilepsy
ترجمه فارسی عنوان
اختلالات شکل محلی در تالاموس و پالیدوم همراه با تشنجات ثانویه عمومی در صرع لوب مرییی لوب
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


- Patients with secondarily generalized tonic-clonic seizures (sGTCS) exhibited shape alterations in the thalamus and pallidum.
- Regional GM deficits are pronounced in patients with medically intractable sGTCS.
- The basal ganglia-thalamo-cortical network may be a contributor to the genesis of sGTCS.

Mesial temporal lobe epilepsy (mTLE) is a common type of drug-resistant epilepsy and secondarily generalized tonic-clonic seizures (sGTCS) have devastating consequences for patients' safety and quality of life. To probe the mechanism underlying the genesis of sGTCS, we investigated the structural differences between patients with and without sGTCS in a cohort of mTLE with radiologically defined unilateral hippocampal sclerosis. We performed voxel-based morphometric analysis of cortex and vertex-wise shape analysis of subcortical structures (the basal ganglia and thalamus) on MRI of 39 patients (21 with and 18 without sGTCS). Comparisons were initially made between sGTCS and non-sGTCS groups, and subsequently made between uncontrolled-sGTCS and controlled-sGTCS subgroups. Regional atrophy of the ipsilateral ventral pallidum (cluster size = 450 voxels, corrected p = 0.047, Max voxel coordinate = 107, 120, 65), medial thalamus (cluster size = 1128 voxels, corrected p = 0.049, Max voxel coordinate = 107, 93, 67), middle frontal gyrus (cluster size = 60 voxels, corrected p < 0.05, Max voxel coordinate = − 30, 49.5, 6), and contralateral posterior cingulate cortex (cluster size = 130 voxels, corrected p < 0.05, Max voxel coordinate = 16.5, − 57, 27) was found in the sGTCS group relative to the non-sGTCS group. Furthermore, the uncontrolled-sGTCS subgroup showed more pronounced atrophy of the ipsilateral medial thalamus (cluster size = 1240 voxels, corrected p = 0.014, Max voxel coordinate = 107, 93, 67) than the controlled-sGTCS subgroup. These findings indicate a central role of thalamus and pallidum in the pathophysiology of sGTCS in mTLE.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 70, Part A, May 2017, Pages 259-264
نویسندگان
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