کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5628432 | 1406374 | 2017 | 12 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: ReviewThe Krushinsky-Molodkina rat strain: The study of audiogenic epilepsy for 65Â years ReviewThe Krushinsky-Molodkina rat strain: The study of audiogenic epilepsy for 65Â years](/preview/png/5628432.png)
- The KÐ rat strain shares all the main features of audiogenic seizure-prone animals.
- KM rats display classic audiogenic kindling phenomena.
- KM rats exposed to special sound protocol display blood flow disturbances in the brain.
- KM rats develop a postictal cataleptic state and are prone to nape skin-pinch-induced catalepsy.
The more recent history and main experimental data for the Krushinsky-Molodkina (KM) audiogenic rat strain are presented. The strain selection started in late 1940. Now this strain is inbred, and two new strains are maintained in a laboratory in parallel. These strains originated from KMÂ ÃÂ Wistar hybrids and were bred (starting from 2000) for no-seizure and intense audiogenic seizure phenotypes, respectively. The experimental evidences of audiogenic seizure physiology were accumulated in parallel with (and usually ahead of) data on other audiogenic-prone strains. The peculiar feature of the KM strain is its vulnerability to brain hemorrhages. Thus, the KM strain is used not only as a genetic model of seizure states, but also as a model of blood flow disturbances in the brain.This article is part of a Special Issue entitled “Genetic and Reflex Epilepsies, Audiogenic Seizures and Strains: From Experimental Models to the Clinic”.
Journal: Epilepsy & Behavior - Volume 71, Part B, June 2017, Pages 130-141