ReviewAn abnormal GABAergic system in the inferior colliculus provides a basis for audiogenic seizures in genetically epilepsy-prone rats

- Neuroanatomical studies of the genetically epilepsy-prone rat (GEPR)
- Increased number of GABAergic neurons in the inferior colliculus of GEPRs
- Small neuronal number correlates with audiogenic seizure scores of GEPR backcrosses
- Studies on the propagation pathways for audiogenic seizures in GEPRs
- This defect may play a role in the initiation of audiogenic seizures in GEPRs

In this review of neuroanatomical studies of the genetically epilepsy-prone rat (GEPR), three main topics will be covered. First, the number of GABAergic neurons and total neurons in the inferior colliculus of GEPRs will be compared to those of the nonepileptic Sprague-Dawley rat. Next, the number of small neurons in the inferior colliculus will be described in both developmental and genetic analyses of GEPRs and their backcrosses. Last, results from two types of studies on the propagation pathways for audiogenic seizures in GEPRs will be shown. Together, these studies demonstrate a unique GABAergic, small neuron defect in the inferior colliculus of GEPRs that may play a vital role in the initiation and spread of seizure activity during audiogenic seizures.This article is part of a Special Issue entitled “Genetic and Reflex Epilepsies, Audiogenic Seizures and Strains: From Experimental Models to the Clinic”.