Case ReportFaciobrachial dystonic seizures result from fronto-temporo-basalganglial network involvement

- Faciobrachial dystonic seizures (FBDS) are caused by autoantibodies to leucine-rich glioma-inactivated1 proteins, a component of the voltage-gated potassium channel complex (VGKC-complex) and precede the clinical presentation of limbic encephalitis.
- The exact pathophysiology of FBDS is not known and whether they are seizures or movement disorder is still debated.
- We suggest the fronto-temporo-basal ganglia network involving the medial frontal and temporal regions along with the corpus striatum and substantia nigra being responsible for the clinical phenomenon of FBDS.
- The varied clinical, electrical and imaging features of FBDS in our cases and in the literature are best explained by involvement of this network.
- Entrainment from any part of this network will result in similar clinical expression of FBDS, whereas other electro-clinical associations and duration depends on the extent of involvement of the network.