کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5629089 1580142 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Monocyte depletion early after stroke promotes neurogenesis from endogenous neural stem cells in adult brain
ترجمه فارسی عنوان
تخریب مونوسیت ها در اوایل پس از سکته مغزی باعث تشدید نوروژنز از سلول های بنیادی عصبی در مغز بزرگسالان می شود.
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


- Depletion of circulating monocytes after stroke enhances striatal neurogenesis
- Infiltrating monocytes compromise survival of newly generated neuroblasts
- Depletion of circulating monocytes after stroke attenuates reactive gliosis
- Infiltrating monocytes do not affect neurogenesis from grafted human NSPCs

Ischemic stroke, caused by middle cerebral artery occlusion, leads to long-lasting formation of new striatal neurons from neural stem/progenitor cells (NSPCs) in the subventricular zone (SVZ) of adult rodents. Concomitantly with this neurogenic response, SVZ exhibits activation of resident microglia and infiltrating monocytes. Here we show that depletion of circulating monocytes, using the anti-CCR2 antibody MC-21 during the first week after stroke, enhances striatal neurogenesis at one week post-insult, most likely by increasing short-term survival of the newly formed neuroblasts in the SVZ and adjacent striatum. Blocking monocyte recruitment did not alter the volume of the ischemic lesion but gave rise to reduced astrocyte activation in SVZ and adjacent striatum, which could contribute to the improved neuroblast survival. A similar decrease of astrocyte activation was found in and around human induced pluripotent stem cell (iPSC)-derived NSPCs transplanted into striatum at one week after stroke in monocyte-depleted mice. However, there was no effect on neurogenesis in the graft as determined 8 weeks after implantation. Our findings demonstrate, for the first time, that a specific cellular component of the early inflammatory reaction in SVZ and adjacent striatum following stroke, i.e., infiltrating monocytes, compromises the short-term neurogenic response neurogenesis from endogenous NSPCs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 297, November 2017, Pages 129-137
نویسندگان
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