کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5629121 1580144 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research PaperCNS disease diminishes the therapeutic functionality of bone marrow mesenchymal stem cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Research PaperCNS disease diminishes the therapeutic functionality of bone marrow mesenchymal stem cells
چکیده انگلیسی


- Mesenchymal stem cells (MSCs) derived from EAE mice fail to ameliorate EAE.
- EAE-MSCs secrete higher levels of pro-inflammatory cytokines.
- Similar functional changes are seen in MSCs from patients with multiple sclerosis.

Mesenchymal stem cells (MSCs) have emerged as a potentially powerful cellular therapy for autoimmune diseases including multiple sclerosis (MS). Based on their success in treating animal models of MS like experimental autoimmune encephalomyelitis (EAE), MSCs have moved rapidly into clinical trials for MS. The majority of these trials use autologous MSCs derived from MS patients, although it remains unclear how CNS disease may affect these cells. Here, we report that bone marrow MSCs derived from EAE mice lack therapeutic efficacy compared to naïve MSCs in their ability to ameliorate EAE. Treatment with conditioned medium from EAE-MSCs also fails to modulate EAE, and EAE-MSCs secrete higher levels of many pro-inflammatory cytokines compared to naïve MSCs. Similarly, MSCs derived from MS patients have less therapeutic efficacy than naïve MSCs in treating EAE and secrete higher levels of some of the same pro-inflammatory cytokines. Thus diseases like EAE and MS diminish the therapeutic functionality of bone marrow MSCs, prompting reevaluation about the ongoing use of autologous MSCs as a treatment for MS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 295, September 2017, Pages 222-232
نویسندگان
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