Anti-C1q autoantibodies in patients with neuromyelitis optica spectrum disorders

- Serum and CSF anti-C1q autoAb levels increase during acute phase NMOSD.
- CSF anti-C1q autoAb levels correlate with other NMOSD CSF biomarkers.
- CSF anti-C1q autoAb levels reflect NMOSD disease severity.

We examined anti-complement C1q (C1q) autoantibody levels in serum and cerebrospinal fluid (CSF) samples of patients with neuromyelitis optica spectrum disorders (NMOSD). We analyzed the correlations between anti-C1q autoantibody levels and the clinical and other CSF characteristics of NMOSD. Serum and CSF anti-C1q autoantibody levels increased during the acute phase of NMOSD, reverting to the same levels as controls during remission. CSF anti-C1q autoantibody levels during the acute phase correlated with several markers reflecting disease severity, Expanded Disability Status Scale worsening, spinal cord lesion length in cases with myelitis, CSF protein and interleukin-6 levels, and CSF/serum albumin ratios.

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