کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5630319 | 1580366 | 2017 | 12 صفحه PDF | دانلود رایگان |

- Secreted factors from cultured B cells from relapsing remitting MS (RRMS) patients, but not normal controls (NC), are cytotoxic to rat and human neurons.
- Cytotoxicity is independent of Ig and multiple cytokines, not complement-mediated, and occurs partially by apoptosis.
- The factor/s are >Â 300Â kDa.
- CNS-compartmentalized B cells (such as meningeal B cells) could mediate subpial demyelination and neuronal/axonal damage by secreting one or more non-immunoglobulin factors, compatible with cortical lesion immunopathology.
B cells mediate multiple sclerosis (MS) pathogenesis by mechanisms unrelated to immunoglobulin (Ig). We reported that supernatants (Sup) from cultured B cells from blood of relapsing remitting MS (RRMS) patients, but not normal controls (NC), were cytotoxic to rat oligodendrocytes (OL). We now show that RRMS blood B cells, not stimulated in vitro, secrete factor/s toxic to rat and human neurons. Cytotoxicity is independent of Ig and multiple cytokines, not complement-mediated, and involves apoptosis. The factor/s have an apparent mw of >Â 300Â kDa. B cells could contribute to damage within the central nervous system by secreting molecules toxic to OL and neurons.
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Journal: Journal of Neuroimmunology - Volume 309, 15 August 2017, Pages 88-99