Neuropathies optiques d'origine mitochondriale

Mitochondrial conditions can often cause optic nerve dysfunction, sometimes as the presenting sign. The most common hereditary optic neuropathies are Leber's hereditary optic neuropathy and autosomal dominant optic atrophy, but other inherited neurological and syndromic conditions are frequently associated with optic neuropathy, due to its vulnerability to the energetic impairment. Mitochondrial dysfunction can also affect the retina (retinitis pigmentosa) and the retrochiasmal visual pathways, as well as the ocular muscles. Although various novel treatments could improve the clinical outcomes in mitochondrial optic neuropathies, they remain widely incurable.