Trials in head and neck oncology: Evolution of perioperative adjuvant therapy

- Postoperative adjuvant therapy has improved survival in advanced stage disease.
- Postoperative RT may improve locoregional control over preoperative RT.
- Fractionated adjuvant RT and neo-adjuvant chemotherapy remain investigational.
- Adjuvant chemoradiation may improve survival with positive margins or ECE.
- Clinical trials requiring careful interpretation to apply the evidence to a single patient.