کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5654803 1589407 2017 30 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immunoglobulin and B-cell disturbances in patients with chronic idiopathic neutropenia
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Immunoglobulin and B-cell disturbances in patients with chronic idiopathic neutropenia
چکیده انگلیسی
Chronic idiopathic neutropenia (CIN) is a granulocytic disorder associated with presence of activated, myelosuppressive T-lymphocytes. In the present study we have evaluated constituents of humoral immunity in CIN patients (n = 48) compared to healthy controls (n = 52). CIN patients displayed lower serum IgG levels due to a reduction in IgG1, IgG3, IgG4 but not IgG2, lower IgA and increased IgM levels compared to controls. The proportion of CD19+ cells did not differ between patients and controls; however the proportion of the naïve IgD+/CD27− B-cells was increased and the proportion of class-switched memory IgD−/CD27+ B-cells was decreased in the patients. The percentage of CD40+ B-cells did not differ between patients and controls and no aberrations in the CD40-meadiated signal transduction pathway or in CD40-gene polymorphisms were identified. These data provide further evidence that immune disturbances are associated with the pathophysiology of CIN and point out for the first time the implication of the B-cell system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 183, October 2017, Pages 75-81
نویسندگان
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