کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5654871 | 1589410 | 2017 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CXCR6 gene characterization in two ethnically distinct South African populations and association with viraemic disease control in HIV-1-infected black South African individuals
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
CXCR6 genetic variation was described for HIV-1-uninfected black (n = 41) and Caucasian (n = 40) South Africans. We also investigated the CXCR6 rs2234358 and rs2234355 single nucleotide polymorphisms in HIV-1 disease control in 124 HIV-1-infected drug-naïve black individuals [elite controllers (n = 11), viraemic controllers (VCs, n = 30), high viral load long-term nonprogressors (HVL LTNPs, n = 11) and progressors (n = 72)] compared to healthy controls (HCs; n = 232). The rs2234358-T allele was underrepresented in VCs (40.0%) compared to HCs (59%, P = 0.006), HVL LTNPs (72.7%, P = 0.012) and progressors (59%, P = 0.014). The rs2234358-TT genotype was underrepresented in VCs (7%) compared to progressors (32%; OR = 6.57, P = 0.006) and HCs (35%; OR = 7.18, P = 0.001, Pbonferroni = 0.034). The rs2234355-GA genotype was overrepresented in VCs (80%) compared to HCs (50.4%; OR = 0.25, P = 0.003) and progressors (29.17%; OR = 0.10, P = 3.8 Ã 10â 5, Pbonferroni = 0.001). The combination of rs2234355-GA in the absence of rs2234358-TT was overrepresented in VCs (80%) compared to HCs (32.6%, OR = 0.12, P = 1 Ã 10â 6, Pbonferroni = 3.4 Ã 10â 5) and to progressors (16.7%; OR = 0.05, P < 1 Ã 10â 8, Pbonferroni < 1 Ã 10â 7).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 180, July 2017, Pages 69-79
Journal: Clinical Immunology - Volume 180, July 2017, Pages 69-79
نویسندگان
Anabela C.P. Picton, Maria Paximadis, Richard E. Chaisson, Neil A. Martinson, Caroline T. Tiemessen,