Specificity protein 1: Its role in colorectal cancer progression and metastasis

- We reviewed Sp1 structure, binding site and biology.
- We discussed the involvement of Sp1 in CRC growth and metastasis.
- We also reviewed Sp1 signaling and its molecular mechanism in CRC.
- Also, we discussed that Sp1 is important for CRC stem cells survival and tumorigenesis.

Specificity protein 1 (Sp1) is a widely expressed transcription factor that plays an important role in the promotion of oncogenes required for tumor survival, progression and metastasis. Sp1 is highly expressed in several cancers including colorectal cancer (CRC) and is related to poor prognosis. Therefore, targeting Sp1 is a rational for CRC therapy. In this review, we will recapitulate the current understanding of Sp1 signaling, its molecular mechanisms, and its potential involvement in CRC growth, progression and metastasis. We will also discuss the current therapeutic drugs for CRC and their mechanism of action via Sp1.