کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5664090 1590704 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impact of hyperglycemia on the efficacy of chemotherapy-A systematic review of preclinical studies
ترجمه فارسی عنوان
تأثیر هیپرگلیسمی بر اثربخشی شیمی درمانی - بررسی سیستماتیک مطالعات پیش از موعد
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
چکیده انگلیسی

BackgroundAntineoplastic agents can provoke hyperglycemia in cancer patients with and without diabetes mellitus. We systematically reviewed the impact of hyperglycemia on the efficacy of chemotherapy.MethodsMEDLINE was searched for preclinical intervention studies which compared chemotherapy response in hyperglycemic and euglycemic conditions.ResultsThirteen preclinical studies, including 23 cell lines and 2 animal experiments were identified. In 14 cell lines and 2 animal studies, chemotherapy response was lower in a hyperglycemic (>15 mmol/L) compared to a euglycemic environment (5 mmol/L). The response was similar in 4 cell lines. In the remaining 5 cell lines, the hyperglycemic environment potentiated chemotherapy efficacy.ConclusionHyperglycemia attenuated the antiproliferative effect of chemotherapy in preclinical experiments, but the results are inconsistent. Whether hyperglycemia influences efficacy of chemotherapy in patients needs to be explored.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Reviews in Oncology/Hematology - Volume 113, May 2017, Pages 235-241
نویسندگان
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