کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5664237 1407679 2017 23 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stem cell transplantation for immunoglobulin light chain amyloidosis
ترجمه فارسی عنوان
پیوند سلول های بنیادی برای آمیلوئیدوز زنجیره ای ایمونوگلوبولین
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
چکیده انگلیسی
Systemic chemotherapy aimed at eradicating transformed plasma cells is the mainstay of treatment for immunoglobulin light chain amyloidosis (AL). Autologous stem cell transplantation (SCT) is a highly effective treatment for AL and can lead to long term survival in excess of 10 years in patients who achieve complete remission. Since AL is a unique disease characterized by multiple organ dysfunction, SCT poses unique challenges in this disease. Morbidity and mortality of SCT has remarkably improved over time primarily due to careful selection of patients and evolution of predictive and prognostic models based on serum immunoglobulin light chains and cardiac biomarkers. In this review we focus on the historical evolution of SCT as a treatment for AL and unique challenges it poses in the management of this rare disease and provide guidelines for managing these challenges.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Problems in Cancer - Volume 41, Issue 2, March–April 2017, Pages 129-137
نویسندگان
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