کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5664548 | 1591021 | 2017 | 4 صفحه PDF | دانلود رایگان |
BackgroundThe PLASMIC score was recently described as a convenient tool for predicting ADAMTS13 activity â¤10% in patients with possible thrombotic thrombocytopenic purpura (TTP), while awaiting the results of this send-out test. The purpose of this study was to validate the PLASMIC score at our University Medical Center.MethodsApheresis records were reviewed from 2008 to 2017 to identify patients who received plasma exchange (PLEX) for suspected TTP. The ADAMTS13 activity and PLASMIC scoring criteria were recorded, and the PLASMIC score was calculated.ResultsOf the 41 patients identified, 20 met inclusion criteria, of which 7 patients had ADAMTS13 activity â¤10%. Intermediate and high PLASMIC scores had 100% sensitivity, 46.2% specificity, 50% positive predictive value (PPV), and 100% negative predictive value (NPV).ConclusionThese results are consistent with the original validation study of the PLASMIC score, supporting the efficacy of the PLASMIC score and validating its use at our institution.
Journal: Transfusion and Apheresis Science - Volume 56, Issue 4, August 2017, Pages 591-594