کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5667000 | 1591739 | 2017 | 8 صفحه PDF | دانلود رایگان |

- Mul-1867 is highly active against planktonic and biofilm-grown Candida and Aspergillus spp. strains.
- Mul-1867 significantly reduced pre-formed fungal biofilm populations starting at a concentration of 1âÃâMFC.
- SEM images showed release of polymeric molecules from fungal cells after 1âmin of challenge with Mul-1867.
- Mul-1867 offers promising potential in future therapies as an inhaled drug to treat pulmonary fungal infections.
There is an urgent need for new antifungal compounds to treat various types of fungal infections, including pulmonary infections. This study was designed to investigate the potency of a novel compound (Mul-1867) against Candida spp. and Aspergillus spp. isolated from patients with fungal pneumonia, cystic fibrosis and chronic obstructive pulmonary disease. Mul-1867 was highly effective against susceptible control strains as well as resistant clinical isolates, with minimum fungicidal concentrations (MFCs) varying from 0.06âµg/mL to 0.5âµg/mL. It was also highly effective against pre-formed 48-h-old biofilms formed by yeasts and moulds. The half-minimal biofilm eradication concentration (MBEC50) was equal to the MFC. The minimum biofilm eradication concentration to eliminate 90% of biofilms (MBEC90) varied from 1âÃâto 4âÃâMFC. Scanning electron microscopy revealed morphological changes accompanied by the release of intracellular material from the fungal cells following exposure to Mul-1867. Furthermore, an increased concentration of nucleic acids was found in the medium after 5âmin and 20âmin of Mul-1867 treatment, indicating leakage of cytoplasmic contents. Overall, these data indicate that Mul-1867 may be a promising inhaled antifungal agent for the treatment and prevention of fungal respiratory infections.
Journal: International Journal of Antimicrobial Agents - Volume 50, Issue 1, July 2017, Pages 47-54