کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5667336 1592040 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
HIV and aging
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
HIV and aging
چکیده انگلیسی


- The world's HIV population is aging; in developed countries, 50% of patients are over the age of 50 years.
- In the effective antiretroviral era, mortality has fallen and life expectancy has increased for HIV patients.
- HIV increases systemic inflammation, but whether HIV accelerates aging is controversial.
- HIV-positive people are at increased risk of co-morbidities.
- The management of HIV patients will increasingly focus on geriatric issues.

With the wider availability of antiretrovirals, the world's HIV population is aging. More than 10% of the 34.5 million HIV-positive individuals worldwide are over the age of 50 years and the average age continues to increase. In the USA more than 50% of the 1.3 million people with HIV are over 50 years old and by the year 2030 it is estimated that 70% will be over the age of 50 years. Although the life expectancy of HIV-positive people has increased dramatically, it still lags behind that of HIV-negative individuals. There is controversy about whether HIV itself accelerates the aging process. Elevated rates of inflammation seen in people with HIV, even if their viral loads are suppressed and their CD4 counts are preserved, are associated with greater rates of cardiovascular, renal, neurocognitive, oncological, and osteoporotic disease. These conditions increase exponentially in the elderly and will represent a major challenge for HIV patients. In addition, conditions such as geriatric syndromes including frailty are also seen at higher rates. Management of the aging HIV patient includes an emphasis on early diagnosis and treatment, preventative measures for co-morbidities, and avoiding polypharmacy. Finally, the issue of quality of life, prioritization of medical issues, and end of life care become increasingly important as the patient grows older.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Infectious Diseases - Volume 53, December 2016, Pages 61-68
نویسندگان
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