کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5668041 1592332 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Limited diagnostic value of a multiplexed gastrointestinal pathogen panel for the detection of adenovirus infection in an oncology patient population
ترجمه فارسی عنوان
ارزش تشخیصی محدود یک پانک پاتوژن مجزا برای تشخیص عفونت آدنویروس در جمعیت بیمار انکولوژی
کلمات کلیدی
آدنویروس، ژنوتایپ ها، گاستروانتریت، پانل مولکولی چندگانه بیماران سرطانی،
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
چکیده انگلیسی


- Adenovirus type C/2 was the most common type recovered in stool samples of an oncology patient population followed by Adenovirus type F40/41.
- Adenovirus type F/40/41 was recovered with high frequency in plasma samples of an oncology patient population.
- Multiplexed GI panel should be more inclusive of a wider variety of adenovirus types for the diagnosis adenoviral infection in cancer patients.

BackgroundDiagnosis of Adenovirus infections in transplant patients may be accomplished using either plasma or stool samples. IVD-cleared multiplexed gastrointestinal (GI) PCR panels offer an option for rapid testing of stool samples but most only target Adenovirus (HAdV) types F40/41.ObjectivesGiven the potential significance of a positive adenovirus test in an immunocompromised patient, we sought to determine the frequency of type 40/41 in our patient population and the utility of a readily available multiplexed, FDA-cleared GI Panel for the detection of adenovirus infections.Study designA total of 215 specimens from immunocompromised patients mostly with hematologic malignancy or transplant recipients were evaluated including 107 plasma samples, 85 stool samples and 23 respiratory samples. Genotyping was performed successfully on 122 specimens.ResultsThe most common type detected in all samples including stools was Adenovirus C/2. In a subset of patients with multiple specimen types tested, similar types were detected in all samples.ConclusionsAlthough Adenovirus F40/41 is the most common enteric type, Adenovirus C/2 was the most common type identified in stools and subsequently plasma samples of our patient population. Implementation of assays that have wide reactivity for most adenovirus types is essential for optimal diagnostic yield.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Virology - Volume 94, September 2017, Pages 37-41
نویسندگان
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