کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5668565 | 1407906 | 2017 | 9 صفحه PDF | دانلود رایگان |

- HIV-1 subtype B genetic diversity in Shanghai was due to multiple introductions.
- Japan and Korea subtype B have become the source of international dissemination.
- HIV-1 subtype Thai-B strain has spread among the MSM population in Shanghai.
- A unique Shanghai subtype B lineage most likely originated from Argentina.
- Among 35 networks, one third of the Shanghai infections were linked to those in other provinces.
SummaryObjectiveTo investigate the viral genetic evolution, spatial origins and patterns of transmission of HIV-1 subtype B in Shanghai, China.MethodsA total of 242 Shanghai subtype B and 1519 reference pol sequences were subjected to phylogenetic inference and genetic transmission network analyses.ResultsPhylogenetic analysis revealed that subtype B strains circulating in Shanghai were genetically diverse and closely associated with viral sequence lineages in Beijing (76 of 242 [31.4%]), Central China (Henan/Hebei/Hunan/Hubei) (43 of 242 [17.8%]), Chinese Taiwan (20 of 242 [8.3%]), Japan (6 of 242 [2.5%]), and Korea (7 of 242 [2.9%]), suggesting multiple introductions into Shanghai from mainland China and Taiwan, Japan, and Korea. Interestingly, a monophyletic Shanghai lineage (SH-L) (36 of 242 [14.9%]) of HIV-1 subtype B most likely originated from an Argentine strain, transferred through Liaoning infected individuals. In-depth analyses of 195 Shanghai subtype B sequences revealed that a total of 37.9% (n = 74) sequences contributed to 35 transmission networks, whereof 33.8% (n = 25) of the sequences associated with infected individuals from other provinces.ConclusionsOur new findings reflect the evolution complexity and transmission dynamics of HIV-1 subtype B in Shanghai, which would provide critical information for the design of effective prevention measures against HIV transmission.
Journal: Journal of Infection - Volume 75, Issue 2, August 2017, Pages 160-168