کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5668607 1407909 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Successful treatment of Pseudomonas aeruginosa osteomyelitis with antibiotic monotherapy of limited duration
ترجمه فارسی عنوان
درمان موفقیتآمیز استئومیلیت پوسیدوموناس آئروژینوزا با آنتی بیوتیک مونوتراپی مدت زمان محدود
کلمات کلیدی
سودوموناس آئروژینوزا، استئومیلیت، استئیتس، آنتی بیوتیک ها، رفتار،
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
چکیده انگلیسی

SummaryObjectivesThe aim of this study was to present a 15-year experience and provide a comprehensive analysis of a large cohort of patients with Pseudomonas aeruginosa osteomyelitis.MethodsWe reviewed the medical records of patients admitted to a large French university hospital for P. aeruginosa osteomyelitis over a 15-year period. Patient outcome was assessed at follow-up after at least six months.ResultsSixty-seven patients were included, comprising 57% with chronic osteomyelitis. Polymicrobial infection was predominant (63%), and an infected device was involved in 39% patients. The overall treatment success rate was 79.1%. All but one patient were treated with a combination of surgery and antibiotic therapy. The antibiotic treatment had a mean duration of 45 days (range, 21-90 days). Single-antibiotic therapy was preferred in nearly all cases. Treatment failure was reported for 14 (21%) patients and was due to the persistence of P. aeruginosa in four cases. No significant risk factor for treatment failure was identified, especially when treatment strategies were compared.ConclusionsWe advocate optimal surgical debridement combined with initial parenteral antibiotics for a maximum of 15 days, followed by an oral fluoroquinolone. Total treatment duration should not exceed six weeks, and antibiotic treatment with two-drug combinations does not seem necessary.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Infection - Volume 75, Issue 3, September 2017, Pages 198-206
نویسندگان
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