Stratégies actuelles de lutte contre la résistance aux antibiotiques

The care of patients of infectious diseases has become a major preoccupation of doctors and brings sometimes to therapeutic impasses due to antibiotic resistance which is the consequence of a genomic and protein adaptations of bacteria. This phenomenon becomes more and more frequent. The WHO qualifies it as a public health problem. This manuscript describes strategies that are actually used to fight against this resistance by improving the structure of the older antibiotics, the combination with beta-lactamases inhibitors, the use of bismuth salt, the substitution by anti-microbial peptide, the blockade of plasmid transfer, the inhibition of ATP synthase and the use of nanoparticles and gene therapy.