کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5672946 | 1593429 | 2017 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ribavirin and boceprevir are able to reduce Canine distemper virus growth in vitro
ترجمه فارسی عنوان
ریباویرین و بوژه ریبیر قادر به کاهش رشد ویروس پوکی استخوان در محیط آزمایشگاهی هستند
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
چکیده انگلیسی
CDV growth in VERO cells was inhibited by ribavirin, by boceprevir and by a combination of the two molecules at non-cytotoxic concentrations, as evaluated by end-point viral titration in cell monolayers and by quantification of viral RNA using quantitative RT-PCR. By end-point titration, a statistically significant reduction in CDV replication was observed only using ribavirin and boceprevir in combination. By quantitative RT-PCR, a significant reduction of viral growth was observed either in cells treated with ribavirin or boceprevir or with both the two molecules. The association of ribavirin or boceprevir was able to decrease CDV growth by up to 3.4458 logs with respect to untreated infected cells, chiefly at the highest virus dilutions. The results obtained in this study may constitute an important basis for the development of CDV therapies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Virological Methods - Volume 248, October 2017, Pages 207-211
Journal: Journal of Virological Methods - Volume 248, October 2017, Pages 207-211
نویسندگان
Gianvito Lanave, Alessandra Cavalli, Vito Martella, Tommaso Fontana, Ruggero Losappio, Maria Tempesta, Nicola Decaro, Domenico Buonavoglia, Michele Camero,