کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5673715 | 1593679 | 2017 | 5 صفحه PDF | دانلود رایگان |
- This study was to investigate the anti-inflammatory effects of sinomenine, an agent found in Chinese herbal medicines.
- Sinomenine could reduce the incidence/severity of LPS-induced toxicities, e.g., cell adhesion and systemic inflammation.
- Sinomenine might effectively be useful to regulate inflammatory responses as part of future anti-endotoxin therapies.
The aim of this study was to investigate in piglets, the anti-endotoxin and anti-inflammatory effects of sinomenine, an agent commonly found in Chinese herbal medicines. In high-, middle- and low-dose sinomenine groups, piglets were initially challenged with endotoxin (i.e., 1Â mg lipopolysaccharide (LPS)/kg) by intraperitoneal (IP) injection and, 3Â h later, intramuscularly (IM) with sinomenine at 1, 5, or 10Â mg/kg. In a drug control group, piglets were dosed IP with vehicle and 3Â h late IM with 10Â mg/kg sinomenine while those in an LPS control group were challenged with 1Â mg LPS/kg (IP) and then vehicle 3Â h later; naïve control piglets were administered normal saline IP and then IM only. At 12, 24, and 48Â h post-LPS/vehicle injection, blood samples were collected from the precaval vein of piglets. Clinical signs were recorded during the trial and index levels were analyzed by ELISA kits. The results revealed sinomenine could reduce the incidence/severity of certain LPS-induced toxicities, e.g., cell adhesion, systemic inflammation, and multiple organ dysfunction. Taken together, the data suggested to us that sinomenine might effectively be useful to regulate inflammatory responses as part of future anti-endotoxin therapies.
Journal: Microbial Pathogenesis - Volume 110, September 2017, Pages 573-577