کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5674664 1408250 2017 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
RNA Regulators: Formidable Modulators of Yersinia Virulence
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
RNA Regulators: Formidable Modulators of Yersinia Virulence
چکیده انگلیسی
A large repertoire of RNA-based regulatory mechanisms, including a plethora of cis- and trans-acting noncoding RNAs (ncRNAs), sensory RNA elements, regulatory RNA-binding proteins, and RNA-degrading enzymes have been uncovered lately as key players in the regulation of metabolism, stress responses, and virulence of the genus Yersinia. Many of them are strictly controlled in response to fluctuating environmental conditions sensed during the course of the infection, and certain riboregulators have already been shown to be crucial for virulence. Some of them are highly conserved among the family Enterobacteriaceae, while others are genus-, species-, or strain-specific and could contribute to the difference in Yersinia pathogenicity. Importantly, the analysis of Yersinia riboregulators has not only uncovered crucial elements and regulatory mechanisms governing host-pathogen interactions, it also revealed exciting new venues for the design of novel anti-infectives.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Trends in Microbiology - Volume 25, Issue 1, January 2017, Pages 19-34
نویسندگان
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